Radiosensitization of C3H Mouse Mammary Tumours by a 2-Nitroimidazole Drug
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چکیده
منابع مشابه
Spontaneous metastasis from primary C3H mouse mammary tumors.
The normal incidence of metastasis was determined in 207 C3H/He and 42 C3Hf/He mice with spontaneous mammary tumors. The effects of early versus delayed surgical removal of the tumors on the incidence of metastasis were studied in the C3H/He mice. The presence of metastases was determined by histological examination, primarily of the lungs. The incidence of metastasis was proportional to the si...
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We have continued our investigation into the mechanism by which nicotinamide can enhance radiation damage in tumors, using a C3H mouse mammary carcinoma grown in CDF1 mice. Biochemical analysis of tumor extracts showed that nicotinamide (1000 mg/kg; i.p.) increased the ATP/Pi and ATP/ADP + AMP ratios. This change in metabolic activity was consistent with nicotinamide increasing tumor oxygenatio...
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BACKGROUND AND PURPOSE Previously, we have reported that 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide (DCQ) is a radiosensitizer. Here, we investigate the mechanism of radiosensitization. MATERIALS AND METHODS EMT6 cells were treated with DCQ for 4h prior to ionizing radiation (IR). Flow cytometry, clonogenic assay, TUNEL, and Western blotting were performed to assess the effect of ...
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The response of a C3H mouse mammary carcinoma to bleomycin was studied in vivo. The dose survival curve exhibited upward concavity, suggesting that the initial sensitive portion was of an exponential nature and that approximately 10% of the tumor cells were in an apparently drug-resistant fraction. The tumor growth was inhibited more effectively by fractionated administrations than by a single ...
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Mouse mammary tumor virus (MMTV) encodes a superantigen (Sag) that is required for efficient milk-borne transmission of virus from mothers to offspring. The mRNA used for Sag expression is controversial, and at least four different promoters (two in the long terminal repeat and two in the envelope gene) for sag mRNA have been reported. To determine which RNA is responsible for Sag function duri...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1974
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1974.235